By S Narasimha Murthy, Howard I. Maibach
Discussing latest ideas, ongoing study, new techniques, and simple ideas within the therapy of nail illnesses, Topical Nail items and Ungual Drug supply summarizes the present wisdom and represents a jumping-off aspect for growing novel options of drug supply around the nail.
A transforming into zone of pharmaceutical examine, the quest for effective supply ideas that could pass the nail barrier has yielded a number of powerful options, introduced jointly during this book.
- Nail anatomy, body structure, illnesses, and treatment
- Permeability of the nail plate
- Topical nail formulations
- Approaches to reinforce ungual and trans-ungual drug delivery
- In vitro and in vivo versions to guage topical nail formulations
- Nail sampling techniques
- Bioengineering of the nail
- Trans-ungual iontophoresis
- Pharmacokinetics of substances within the nail apparatus
- Onychopharmacokinetics: proposed version insight
- Photodynamic remedy of nail diseases
- The nail as a surrogate for investigating drug use
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Discussing present strategies, ongoing examine, new techniques, and uncomplicated recommendations within the remedy of nail illnesses, Topical Nail items and Ungual Drug supply summarizes the present wisdom and represents a jumping-off aspect for developing novel options of drug supply around the nail. A growing to be zone of pharmaceutical study, the quest for effective supply ideas which can move the nail barrier has yielded numerous powerful recommendations, introduced jointly during this e-book.
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Extra info for Topical Nail Products and Ungual Drug Delivery
Archives of Dermatological Research 258 (1): 94. Gilchrist, M. , and L. H. Dudley Buxton. 1939. ” Journal of Anatomy 73: 575–82. , O. F. Nielsen, D. H. Christensen, and H. C. Wulf. 1998. ” Journal of Investigative Dermatology 110 (4): 393–98. Gonzalez-Serva, A. 1997. ” In Nails: Therapy, Diagnosis, Surgery, edited by R. K. Scher and C. R. Daniel. Philadelphia: WB Saunders. , and G. B. Kasting. 2006. ” Journal of Cosmetic Science 57 (2): 183–84. Gunt, H. , and G. B. Kasting. 2007. ” European Journal of Pharmaceutical Sciences 32 (4–5): 254–60.
Keratin binding becomes beneficial for therapy by providing a drug reservoir in the nail plate, such that systemic treatment can be given in pulses. On the other hand, during topical therapy, the drug penetrates the nail plate following application to its dorsal surface—a very good barrier to drug penetration. Keratin binding to the small amounts of drug that permeated into the nail plate could result in insufficient free drug available for antifungal activity. Drug binding to keratin in this case would have an adverse effect on antifungal activity.
Gonzalez-Serva, A. 1997. ” In Nails: Therapy, Diagnosis, Surgery, edited by R. K. Scher and C. R. Daniel. Philadelphia: WB Saunders. , and G. B. Kasting. 2006. ” Journal of Cosmetic Science 57 (2): 183–84. Gunt, H. , and G. B. Kasting. 2007. ” European Journal of Pharmaceutical Sciences 32 (4–5): 254–60. Gupchup, G. , and J. L. Zatz. 1999. ” Journal of Cosmetic Science 50 (6): 363–85. Gupta, A. , and L. E. Lynch. 2004. ” Cutis 74 (1): 5–9. Gupta, A. , and N. H. Shear. 1997. ” Canadian Family Physician 43: 299–305.
Topical Nail Products and Ungual Drug Delivery by S Narasimha Murthy, Howard I. Maibach