Colloid and interface science in pharmaceutical research and by Hiroyuki Ohshima, Kimiko Makino PDF

By Hiroyuki Ohshima, Kimiko Makino

ISBN-10: 044462614X

ISBN-13: 9780444626141

ISBN-10: 1306992842

ISBN-13: 9781306992848

Colloid and Interface technology in Pharmaceutical examine and Development describes the function of colloid and floor chemistry within the pharmaceutical sciences. It supplies a close account of colloid conception, and explains physicochemical houses of the colloidal-pharmaceutical platforms, and the equipment for his or her dimension.

The e-book begins with basics partially I, protecting basic facets of colloid and interface sciences as utilized to pharmaceutical sciences and hence might be compatible for instructing. components II and III deal with purposes and measurements, and so they explains the appliance of those houses and their effect and use for the improvement of latest medicinal drugs.

  • Provides a transparent description of the basics of colloid and interface technological know-how appropriate to drug learn and development
  • Explains the physicochemical/colloidal foundation of pharmaceutical science
  • Lists glossy experimental characterization thoughts, offers analytical equations and factors on interpreting the experimental data
  • Describes the main complicated concepts, AFM (Atomic strength Microscopy), SFA (Surface strength equipment) in detail

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Additional resources for Colloid and interface science in pharmaceutical research and development

Example text

A. Fornes, Colloid Polym. Sci. 263 (1985) 1004. 1 General Introduction ........................................................................................ 2 Disperse Systems ............................................................................................ 1 Thermodynamic Considerations ....................................................... 2 Kinetic Stability of Disperse Systems and the General Stabilisation Mechanisms ..................................................................................

A long PPO chain was also important to ensure anchoring of the block copolymer to the surface. The particle size of the polystyrene particles was also important. 60 and 150 nm particles coated with Poloxamer 407 were not sequestered by the macrophages in the bone marrow (they avoided capture by the Kupffer cells). In contrast to the 250 nm particles (also coated with Poloxamer 207) which were sequestered by the spleen and liver and only a small portion reached the bone marrow. (ii) Chemically grafting the PEG chains.

Particles <200 nm decrease splenic uptake and the particles are cleared by the liver and bone marrow. Colloidal particles not cleared by the RES can potentially exit the blood circulation via the sinusoidal fenestration of the liver and bone marrow. (ii) Surface charge. Surface charges only influence the particle–protein or particle– macrophage interactions at very short distances. The surface charge may affect the surface hydrophobicity which can affect protein adsorption. (iii) Surface hydrophobicity.

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Colloid and interface science in pharmaceutical research and development by Hiroyuki Ohshima, Kimiko Makino


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