New PDF release: Chiral Separations: Methods and Protocols

By Gerald Gübitz, Martin G. Schmid

ISBN-10: 1588291502

ISBN-13: 9781588291509

Tools for enantiomer separation are vitally important for controlling synthesis, for checking race-mization, for enantiomeric purity keep an eye on, and for pharmacokinetic reports. In Chiral Separations: equipment and Protocols, popular specialists from around the globe aspect the chromatographic and electroseparation ideas they've got constructed for chiral separations on an analytical scale. defined in step by step aspect to make sure winning experimental effects, the approaches are offered as both common tools or as particular purposes to substance periods and distinctive compounds, with emphasis on excessive functionality liquid chromatography and capillary electrophoresis concepts, but additionally together with skinny layer chromotographic, fuel chromatographic, and supercritical fluid chromatographic in addition to contemporary electrochromotographic ideas. every one absolutely verified protocol comprises an advent to the main underlying the tactic, apparatus and reagent lists, and beneficial notes on troubleshooting and averting recognized pitfalls. updated and hugely functional, Chiral Separations: equipment and Protocols might help either beginner and complicated clients not just pick out optimum tools for his or her separation difficulties, but additionally without problems receive profitable effects.

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Bhushan, R. and Martens, J. (1997) Direct resolution of enantiomers by impregnated TLC. Biomed. Chromatogr. 11, 280–285. 52 Günther et al. 107. Armstrong, D. , He, F. , and Han, S. M. (1988) Planar chromatographic separation of enantiomers and diastereomers with cyclodextrin mobile phase additives. J. Chromatogr. 448, 345–354. 108. Armstrong, D. , Faulkner, J. , and Han, S. M. (1988) Use of hydroxypropyl- and hydroxyethyl-derivatized β-cyclodextrins for the thin-layer chromatographic separation of enantiomers and diastereomers.

And Senoh, S. (1951) Resolution into optical isomers of some amino acids by paper chromatography. J. Am. Chem. Soc. 73, 2973–2974. 33. Bonino, G. B. and Carassiti, V. (1951) Separation of the optical antipodes of racemic β-naphthol benzylamine by paper chromatography. Nature 167, 569–570. 34. , and Adembri, G. (1951) Ricerche sugli aminoacidi rotatori. -Nota XII. Sperimentale. Sez. Chim. Biol. 2, 89–94. 35. Fujisawa, Y. (1951) Resolution of the racemic amino acids on the paper chromatograms. J.

16. Hubert, P. and Dellacherie, E. (1973) Thin-layer chromatographic separation of dipeptide and tripeptide diastereoisomers. J. Chromatogr. 80, 144–145. 17. , and Sokolowska, T. (1976) Separation of diastereomers of protected dipeptides by thin-layer chromatography. Chromatographia 9, 123–126. 18. , Desideri, P. , and Giannessi, S. (1983) High-performance thin-layer chromatography of diastereomeric di- and tripeptides on readyfor-use plates of silanized silica gel and on ammonium tungstophosphate layers.

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Chiral Separations: Methods and Protocols by Gerald Gübitz, Martin G. Schmid

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