By Brian L. Duke
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Extra resources for Chinese Herbs and Herbal Medicine Essential Components, Clinical Applications and Health Benefits.
The mechanism of action of Aloe vera and its components in promoting wound epithelialization occurs via the activation of certain growth factors (Figure 5). 5 kDa, stimulates epidermal proliferation in cell culture, concomitant with an increase in the expression of proliferation markers, including EGF receptor, fibronectin receptor, fibronectin, keratin 5/14 and keratin 1/10. This fraction also accelerates the migration of human keratinocytes. The stimulating effects of this fraction on both cell proliferation and migration thus underlie the wound healing effects of Aloe vera .
Also confirmed the angiogenic effects of beta-sitosterol isolated from Aloe vera gel on the damaged blood vessels of Mongolian gerbil brains using ischemia/reperfusion. Moreover, they demonstrated an increase in the expression levels of proteins involved in angiogenesis, such as VEGF, VEGF-R2 or fetal liver kinase-1 (Flk-1), von Willebrand factor (a marker for blood endothelial cells), and blood vessel matrix laminin (a principal component of the basement membranes that underlie the endothelium) .
Reported that Aloe vera might expedite the turnover rate of these inflammatory cytokines that cause wound healing processes to resolve rapidly . A member of the gelatinase family of MMPs, MMP-9, which is known to have many pro-inflammatory actions in wound healing, is also downregulated by Aloe vera. An observation reported by Vijayalakshmi et al. suggested that the anti-inflammatory activity of Aloe vera is mediated by inhibition of the activity and production of MMP-9 in peripheral blood mononuclear cells .
Chinese Herbs and Herbal Medicine Essential Components, Clinical Applications and Health Benefits. by Brian L. Duke