New PDF release: Chinese Herbs and Herbal Medicine Essential Components,

By Brian L. Duke

ISBN-10: 1634820851

ISBN-13: 9781634820851

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Extra resources for Chinese Herbs and Herbal Medicine Essential Components, Clinical Applications and Health Benefits.

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The mechanism of action of Aloe vera and its components in promoting wound epithelialization occurs via the activation of certain growth factors (Figure 5). 5 kDa, stimulates epidermal proliferation in cell culture, concomitant with an increase in the expression of proliferation markers, including EGF receptor, fibronectin receptor, fibronectin, keratin 5/14 and keratin 1/10. This fraction also accelerates the migration of human keratinocytes. The stimulating effects of this fraction on both cell proliferation and migration thus underlie the wound healing effects of Aloe vera [168].

Also confirmed the angiogenic effects of beta-sitosterol isolated from Aloe vera gel on the damaged blood vessels of Mongolian gerbil brains using ischemia/reperfusion. Moreover, they demonstrated an increase in the expression levels of proteins involved in angiogenesis, such as VEGF, VEGF-R2 or fetal liver kinase-1 (Flk-1), von Willebrand factor (a marker for blood endothelial cells), and blood vessel matrix laminin (a principal component of the basement membranes that underlie the endothelium) [161].

Reported that Aloe vera might expedite the turnover rate of these inflammatory cytokines that cause wound healing processes to resolve rapidly [90]. A member of the gelatinase family of MMPs, MMP-9, which is known to have many pro-inflammatory actions in wound healing, is also downregulated by Aloe vera. An observation reported by Vijayalakshmi et al. suggested that the anti-inflammatory activity of Aloe vera is mediated by inhibition of the activity and production of MMP-9 in peripheral blood mononuclear cells [133].

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Chinese Herbs and Herbal Medicine Essential Components, Clinical Applications and Health Benefits. by Brian L. Duke


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