Read e-book online Applications of Microdialysis in Pharmaceutical Science PDF

By Tung-Hu Tsai

ISBN-10: 0470409282

ISBN-13: 9780470409282

Discover new and rising purposes for microdialysis in drug evaluation

Microdialysis is a hugely important sampling instrument that may be utilized in vivo to degree loose, unbound analyte concentrations situated in interstitial and extracellular areas. This publication explores the total diversity of medical purposes for microdialysis, targeting its use in several organ and tissue structures for pharmacokinetic and pharmacodynamic stories. Readers achieve an entire figuring out of the underlying technology of microdialysis, present concepts and practices, in addition to its many functions in pharmaceutical research.

Applications of Microdialysis in Pharmaceutical technology starts off with an advent to simple ideas after which covers analytical issues, pharmacodynamic and pharmacokinetic reviews, medical facets, and precise functions. issues include:

  • Role of microdialysis in drug improvement, together with the most important sampling concerns and functions for anxious approach diseases

  • Continuous size of glucose concentrations in diabetics

  • Applications for scientific review and uncomplicated learn on organ structures, together with tracking exogenous and endogenous compounds within the lungs

  • Pharmacokinetic and pharmacodynamic assessment of anticancer drugs

  • Comparison of microdialysis with imaging ways to guage in vivo drug distribution

  • Special functions of microdialysis in experiences of phone tradition assays, drug-drug interactions, and environmental monitoring

Throughout the booklet, readers will locate uncomplicated versions that make clear complicated options and easy-to-follow examples that consultant them via key functions in pharmaceutical examine. briefly, this e-book permits pharmaceutical researchers to take complete good thing about microdialysis ideas for the preclinical and medical review of gear and masses extra.

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Extra info for Applications of Microdialysis in Pharmaceutical Science

Example text

In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol. Pharmaceutical Research, 10, 335–342. , Kehr, J. (2004). Application of triple-probe microdialysis for fast pharmacokinetic/pharmacodynamic evaluation of dopamimetic activity of drug candidates in rat brain. Journal of Neuroscience Methods, 140, 59–65. , Müller, M. (2004). Methods to assess tissue-specific distribution and metabolism of drugs. Current Drug Metabolism, 5, 463–481. [29] Nutt, R.

Accessed November 2008. , Couet, W. (2004). Simultaneous central nervous system distribution and pharmacokinetic– pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats. British Journal of Pharmacology, 142, 323–330. [58] European Medicines Agency (2006). pdf. Accessed November 2008. , Adell, A. (2006). The use of brain microdialysis in antidepressant drug research. I. ), Handbook of Microdialysis: Methods, Applications and Perspectives, Elsevier, Amsterdam, pp.

Development of translational pharmacokinetic– pharmacodynamic models. Clinical Pharmacology & Therapeutics, 83, 909–912. , Sinha, V. (2005). Pharmacokinetics/pharmacodynamics and the stages of drug development: role of modeling and simulation. AAPS Journal, 7, E544–E559. K. (2000). ADME/PK as part of a rational approach to drug discovery. Drug Discovery Today, 5, 414. S. (2007). Improving early drud discovery through ADME modelling. Drugs in R & D, 8, 349–362. H. (2002). Pharmacokinetic imaging a noninvasive method for determining drug distribution and action.

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Applications of Microdialysis in Pharmaceutical Science by Tung-Hu Tsai

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