By Jeremy I Levin; Stefan Laufer
Content material: part 1. Arachidonic acid cascade -- part 2. Kinases -- part three. GPCRs -- part four. Sphingolipids -- part five. Steroid hormone receptors
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Extra info for Anti-Inflammatory Drug Discovery
44 In the following, the focus will be directed towards cPLA2a, which plays a key function in the development of inﬂammatory processes. 1–7,25–27 On agonist-induced stimulation it translocates from the cytosol to cellular membranes, where it is bound via its calciumphospholipid binding domain. 45–47 Furthermore, its expression is increased by these cytokines. 1 Role of cytosolic phospholipase A2a in the inﬂammatory cascade. 38 Chapter 2 48 acid of the phospholipid substrate and an active site serine residue.
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Anti-Inflammatory Drug Discovery by Jeremy I Levin; Stefan Laufer