Get Anti-Inflammatory Drug Discovery PDF

By Jeremy I Levin; Stefan Laufer

ISBN-10: 1849734135

ISBN-13: 9781849734134

ISBN-10: 1849735344

ISBN-13: 9781849735346

Content material: part 1. Arachidonic acid cascade -- part 2. Kinases -- part three. GPCRs -- part four. Sphingolipids -- part five. Steroid hormone receptors

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Extra info for Anti-Inflammatory Drug Discovery

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44 In the following, the focus will be directed towards cPLA2a, which plays a key function in the development of inflammatory processes. 1–7,25–27 On agonist-induced stimulation it translocates from the cytosol to cellular membranes, where it is bound via its calciumphospholipid binding domain. 45–47 Furthermore, its expression is increased by these cytokines. 1 Role of cytosolic phospholipase A2a in the inflammatory cascade. 38 Chapter 2 48 acid of the phospholipid substrate and an active site serine residue.

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Wada, T. Hiratsuka, S. Futagami, Y. Fukuda, T. Kiyama, T. Tajiri, K. Miyake and C. Sakamoto, Hum. , 2007, 38, 1826. 85. T. Soma, Y. Shimada, A. Kawabe, J. Kaganoi, K. Kondo, M. Imamura and S. Uemoto, Dis. Esophagus, 2007, 20, 123. 86. B. H. von Rahden, H. J. Stein, S. A. Hartl, J. Theisen, B. Stigler, J. R. Siewert and M. Sarbia, Dis. Esophagus, 2008, 21, 304. 87. R. Kawata, S. Hyo, T. Maeda, Y. Urade and H. , 2006, 126, 627. 88. K. Yoshimatsu, N. K. Altorki, D. Golijanin, F. Zhang, P. J. Jakobsson, A.

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Anti-Inflammatory Drug Discovery by Jeremy I Levin; Stefan Laufer


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