New PDF release: Aging and Cancer

By Frederick F. Holmes M.D. (auth.)

ISBN-10: 3642821014

ISBN-13: 9783642821011

ISBN-10: 3642821030

ISBN-13: 9783642821035

The lifetime of a individual is finite, and all people age (see Fries 1980). it really is tough to split the results of ailment on organs and tissues from these anticipated of getting older. this can be really precise for vascular and degenerative methods, for which there are not any transparent barriers among getting older and affliction. Morbidity and mortality from center ailment and stroke are most likely due either to disorder and to adjustments of getting older. For melanoma, the second one major reason behind loss of life in the USA, the placement is sort of diverse; melanoma is obviously a disorder and isn't a metamorphosis anticipated with getting older. melanoma prevalence raises virtually logarithmically after age forty. within the usa approximately one-half of all circumstances of melanoma are clinically determined after age sixty five, even if these over sixty five contain below one-eighth of the inhabitants. therefore, melanoma is especially a lot a disorder of the aged. There are a minimum of purposes for this: first, the lengthy publicity to cancer-inducing brokers, and moment, the waning energy of immune defenses opposed to cancer.

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The major preoccupation of the pancreatic cancer therapy literature of recent years is with the operation that gives the best and longest palliation. This issue is by no means resolved, though some sort of biliary tract diversion seems to be appropriate. Attempts at tumor resection are fraught with high postoperative morbidity and mortality and are rarely justified, especially in the elderly. - Fig. 1. Incidence of pancreatic cancer in USA 1973-1977 eO-I. 15-81 70-74 AGE IN YEARS 75-7' 80-84 85.

40 30 20 '0 0 I 3 65-74 I 5 I 3 75-84 3 85-94 Fig. 3. J ~ :;: so a: :I II) 40 30 20 10 0 3 65-74 I 3 75-84 3 85-94 Fig. 4. Years survival by age and time groups for distantly spread cervical cancer Distant 41 Distant There is not a sufficient number of cases for plotting survival curves for any of the three age groups (Fig. 4). Perhaps this is a good omen, because distantly spread cervical cancer is essentially an untreatable disease. For all intents and purposes chemotherapy is without effect.

4). Perhaps this is a good omen, because distantly spread cervical cancer is essentially an untreatable disease. For all intents and purposes chemotherapy is without effect. References Badib AO, Kurohana SS, Webster JH (1970) Radiotherapy of carcinoma of the cervix in the aged. Geriatrics 25: 108-112 Beral V (1974) Cancer of the cervix: a sexually transmitted infection? Lancet 1: 1037-1040 Gellman DD (1976) Epidemiology and natural history of carcinoma of the cervix. Can Med Assoc J 114: 1003-1012 Lewis DR (1966) Management of cervical carcinoma in the elderly patient.

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Aging and Cancer by Frederick F. Holmes M.D. (auth.)


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