By Robert A. Goodnow Jr.
This publication comprehensively describes the advance and perform of DNA-encoded library synthesis know-how. jointly, the chapters element an method of drug discovery that gives an enticing addition to the portfolio of present hit new release applied sciences reminiscent of high-throughput screening, structure-based drug discovery and fragment-based screening. The book:
- Provides a worthy advisor for knowing and making use of DNA-encoded combinatorial chemistry
- Helps chemists generate and monitor novel chemical libraries of enormous measurement and caliber
- Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
- Shows medicinal and pharmaceutical chemists find out how to successfully expand on hand “chemical house” for drug discovery
- Provides professional and updated precis of pronounced literature for DNA-encoded and DNA-directed chemistry know-how and methods
Read Online or Download A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery PDF
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Extra info for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
Oxford. 13. Sambrook, J. , Russell, D. W. (2001). Molecular Cloning: A Laboratory Manual, 3rd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. 14. Fenn, J. , Meng, C. , Wong, S. , Whitehouse, C. M. (1989). Electrospray ionization for mass spectrometry of large biomolecules. Science, 246, 64–71. 15. , Chakel, J. , Hancock, W. S. (1997). Analysis of oligonucleotides by HPLC-electrospray ionization mass spectrometry. Anal. , 69, 1320–1325. 16. , Bischoff, R. (1994). Negative electrospray ionization mass spectrometry of synthetic and chemically modified oligonucleotides.
34, e22. 28. , Kim, D. , Marma, M. , Edwards, J. , Turro, N. J. (2006). Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators. Proc. Natl. Acad. Sci. U. S. , 103, 19635–19640. 29. , Tairi, A. P. (2008). A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis. , 36, e25. 30. , Altman W. , Bader, J. , Bemben, L. , Braverman, M. , Chen, Y. , Dewell, S. , Fierro, J. , Gomes, X.
DNA sequencing technologies are still rapidly expanding and improving, resulting in increased speed and capacity with reduction of cost. They greatly accelerate progress in biomedical research, forensics, agriculture, and diagnostics and enable novel technologies such as DEL. One expects the impact of high-throughput sequencing to continue to have an impact on the practice and applications of DNA-encoded chemistry methods. References 1. Dahm, R. (2008). Discovering DNA: Friedrich Miescher and the early years of nucleic acid research.
A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery by Robert A. Goodnow Jr.